Adenosine Dysfunction and Adenosine Kinase in Epileptogenesis
نویسندگان
چکیده
منابع مشابه
Adenosine dysfunction and adenosine kinase in epileptogenesis.
Traditionally, epilepsy has been considered to be a disorder of neuronal dysfunction. Based on this dogma, drug development efforts have largely focused on neurocentric model systems to screen for compounds that affect the function of neurons. Unfortunately, about 30% of all patients with epilepsy - or more than 20 million worldwide - are refractory to classical neurocentric pharmacotherapy. Th...
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Endogenous adenosine in the brain is thought to prevent the development and spread of seizures via a tonic anticonvulsant effect. Brain levels of adenosine are primarily regulated by the activity of adenosine kinase. To establish a link between adenosine kinase expression and seizure activity, we analyzed the expression of adenosine kinase in the brain of control mice and in a kainic acid-induc...
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Astrogliosis is a pathological hallmark of the epileptic brain. The identification of mechanisms that link astrogliosis to neuronal dysfunction in epilepsy may provide new avenues for therapeutic intervention. Here we show that astrocyte-expressed adenosine kinase (ADK), a key negative regulator of the brain inhibitory molecule adenosine, is a potential predictor and modulator of epileptogenesi...
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10.4172/Neuropsychiatry.1000150 © 2016 pISSN 1758-2008 eISSN 1758-2016 Neuropsychiatry (London) (2016) 6(5), 280–285 280 1Department of Neurology, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China 2Department of Neusurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing, China 3Beijing Key labartory of Epilepsy, Beijing, China 4Center of Epilepsy, Beiji...
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Clinical radiation therapy for the treatment of CNS cancers leads to unintended and debilitating impairments in cognition. Radiation-induced cognitive dysfunction is long lasting; however, the underlying molecular and cellular mechanisms are still not well established. Since ionizing radiation causes microglial and astroglial activation, we hypothesized that maladaptive changes in astrocyte fun...
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ژورنال
عنوان ژورنال: The Open Neuroscience Journal
سال: 2010
ISSN: 1874-0820
DOI: 10.2174/1874082001004010093